Exploiting innate immunity for cancer immunotherapy
Shanxi Medical University · Shanxi Academy of Medical Sciences · +7 more institutions
Abstract
Immunotherapies have revolutionized the treatment paradigms of various types of cancers. However, most of these immunomodulatory strategies focus on harnessing adaptive immunity, mainly by inhibiting immunosuppressive signaling with immune checkpoint blockade, or enhancing immunostimulatory signaling with bispecific T cell engager and chimeric antigen receptor (CAR)-T cell. Although these agents have already achieved great success, only a tiny percentage of patients could benefit from immunotherapies. Actually, immunotherapy efficacy is determined by multiple components in the tumor microenvironment beyond adaptive immunity. Cells from the innate arm of the immune system, such as macrophages, dendritic cells,…
Citation impact
- FWCI
- 35.21
- Percentile
- 100%
- References
- 905
Authors
8- MYMing YiCorresponding
Shanxi Medical University, Shanxi Academy of Medical Sciences, First Affiliated Hospital Zhejiang University, Zhejiang University
- TLTianye Li
Second Affiliated Hospital of Zhejiang University
- MNMengke Niu
Tongji Hospital, Huazhong University of Science and Technology
- QMQi Mei
Shanxi Medical University, Shanxi Academy of Medical Sciences
- BZBin Zhao
First Affiliated Hospital Zhejiang University, Zhejiang University
Topics & keywords
- Innate immune system
- Immunotherapy
- Biology
- Immunology
- Acquired immune system
- Immune system
- Cancer immunotherapy
- Immunity
- Good health and well-being