articleNucleic Acids ResearchNov 28, 2023GOLD OA

MODOMICS: a database of RNA modifications and related information. 2023 update

ACAndrea CappanniniARAngana RayEPElżbieta PurtaSMSunandan MukherjeePBPietro Boccaletto

International Institute of Molecular and Cell Biology · Centre National de la Recherche Scientifique · +3 more institutions

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Abstract

The MODOMICS database was updated with recent data and now includes new data types related to RNA modifications. Changes to the database include an expanded modification catalog, encompassing both natural and synthetic residues identified in RNA structures. This addition aids in representing RNA sequences from the RCSB PDB database more effectively. To manage the increased number of modifications, adjustments to the nomenclature system were made. Updates in the RNA sequences section include the addition of new sequences and the reintroduction of sequence alignments for tRNAs and rRNAs. The protein section was updated and connected to structures from the RCSB PDB database and predictions by AlphaFold. MODOMICS…

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Topics & keywords

Topics
Keywords
  • Protein Data Bank (RCSB PDB)
  • RNA
  • Biology
  • Annotation
  • Database
  • Computational biology
  • Computer science
  • Bioinformatics
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