An Update on Management of Adult Patients with Acute Respiratory Distress Syndrome: An Official American Thoracic Society Clinical Practice Guideline

Abstract Background This document updates previously published Clinical Practice Guidelines for the management of patients with acute respiratory distress syndrome (ARDS), incorporating new evidence addressing the use of corticosteroids, venovenous extracorporeal membrane oxygenation, neuromuscular blocking agents, and positive end-expiratory pressure (PEEP). Methods We summarized evidence addressing four “PICO questions” (patient, intervention, comparison, and outcome). A multidisciplinary panel with expertise in ARDS used the Grading of Recommendations, Assessment, Development, and Evaluation framework to develop clinical recommendations. Results We suggest the use of: 1) corticosteroids for patients with…

• UD
  U.S. Department of Defense
• GA
  Gordon and Betty Moore Foundation
• GS
  Gilead Sciences
• SO
  School of Medicine, Boston University
• CC
  Cleveland Clinic
• JH
  Johns Hopkins University
• MU
  McMaster University
• SL
  Saint Louis University
• L
  LivaNova
• ZM
  ZOLL Medical Corporation
• IC
  Intensive Care Society
• MU
  Monash University
• UO
  University of Toronto
• UD
  Università degli Studi di Trento
• CU
  Clermont Université
• SD
  Société de Réanimation de Langue Française
• AP
  Assistance publique-Hôpitaux de Paris
• UD
  Université de Versailles Saint-Quentin-en-Yvelines
• NI
  National Institutes of Health
• CF
  Centers for Disease Control and Prevention
• AF
  Agency for Healthcare Research and Quality
• UO
  University of California, San Francisco
• CI
  Canadian Institutes of Health Research
• LD
  Leslie Dan Faculty of Pharmacy, University of Toronto
• NH
  National Heart, Lung, and Blood Institute
• NI
  National Institute on Drug Abuse
• DO
  Department of Medicine, University of California, San Francisco
• DG
  David Geffen School of Medicine, University of California, Los Angeles