Gut liver brain axis in diseases: the implications for therapeutic interventions
Tianjin University of Science and Technology · China International Science and Technology Cooperation · +4 more institutions
Abstract
Gut-liver-brain axis is a three-way highway of information interaction system among the gastrointestinal tract, liver, and nervous systems. In the past few decades, breakthrough progress has been made in the gut liver brain axis, mainly through understanding its formation mechanism and increasing treatment strategies. In this review, we discuss various complex networks including barrier permeability, gut hormones, gut microbial metabolites, vagus nerve, neurotransmitters, immunity, brain toxic metabolites, β-amyloid (Aβ) metabolism, and epigenetic regulation in the gut-liver-brain axis. Some therapies containing antibiotics, probiotics, prebiotics, synbiotics, fecal microbiota transplantation (FMT),…
Citation impact
- FWCI
- 34.62
- Percentile
- 100%
- References
- 497
Authors
7- MYMengyao Yan
Tianjin University of Science and Technology, China International Science and Technology Cooperation
- SMShuli Man
Tianjin University of Science and Technology, China International Science and Technology Cooperation
- BSBenyue Sun
Tianjin University of Science and Technology, China International Science and Technology Cooperation
- LMLong Ma
Tianjin University of Science and Technology, China International Science and Technology Cooperation
- LGLanping Guo
Chinese Academy of Medical Sciences & Peking Union Medical College, China Academy of Chinese Medical Sciences
Topics & keywords
- Gut–brain axis
- Gut flora
- Farnesoid X receptor
- Gastrointestinal tract
- Medicine
- Synbiotics
- Bioinformatics
- Neuroscience
- Good health and well-being