Organ aging signatures in the plasma proteome track health and disease

Abstract Animal studies show aging varies between individuals as well as between organs within an individual 1–4 , but whether this is true in humans and its effect on age-related diseases is unknown. We utilized levels of human blood plasma proteins originating from specific organs to measure organ-specific aging differences in living individuals. Using machine learning models, we analysed aging in 11 major organs and estimated organ age reproducibly in five independent cohorts encompassing 5,676 adults across the human lifespan. We discovered nearly 20% of the population show strongly accelerated age in one organ and 1.7% are multi-organ agers. Accelerated organ aging confers 20–50% higher mortality risk,…

• NS
  National Science Foundation

  Awards: RF1AG053303, U01AG058922, R01AG044546, RF1AG058501, P01AG003991
• AA
  Alzheimer's Association

  Awards: ZEN-22-848604, P50AG047366
• NI
  National Institutes of Health

  Awards: AG057909, AG066206, U01AG058922, RF1AG053303, RF1AG074007, P30AG066515, R01AG044546, P50AG047366, P01AG003991, RF1AG058501