Risk of metabolic abnormalities in osteoarthritis: a new perspective to understand its pathological mechanisms

Although aging has traditionally been viewed as the most important risk factor for osteoarthritis (OA), an increasing amount of epidemiological evidence has highlighted the association between metabolic abnormalities and OA, particularly in younger individuals. Metabolic abnormalities, such as obesity and type II diabetes, are strongly linked to OA, and they affect both weight-bearing and non-weight-bearing joints, thus suggesting that the pathogenesis of OA is more complicated than the mechanical stress induced by overweight. This review aims to explore the recent advances in research on the relationship between metabolic abnormalities and OA risk, including the impact of abnormal glucose and lipid…

• NS
  National Science Foundation
• NN
  National Natural Science Foundation of China

  Awards: 82360429, 82161160342, 82250710174, 82030067, 82172397
• CP
  China Postdoctoral Science Foundation
• GM
  Guangxi Medical University
• NK
  National Key Research and Development Program of China

  Award: 2021YFB3800800
• SI
  Shenzhen Institutes of Advanced Technology Innovation Program for Excellent Young Researchers