Targeting hypoxia-inducible factors: therapeutic opportunities and challenges
The University of Texas Health Science Center · The University of Texas Health Science Center at Houston · +7 more institutions
Abstract
Hypoxia-inducible factors (HIFs) are highly conserved transcription factors that are crucial for adaptation of metazoans to limited oxygen availability. Recently, HIF activation and inhibition have emerged as therapeutic targets in various human diseases. Pharmacologically desirable effects of HIF activation include erythropoiesis stimulation, cellular metabolism optimization during hypoxia and adaptive responses during ischaemia and inflammation. By contrast, HIF inhibition has been explored as a therapy for various cancers, retinal neovascularization and pulmonary hypertension. This Review discusses the biochemical mechanisms that control HIF stabilization and the molecular strategies that can be exploited…
Citation impact
- FWCI
- 43.62
- Percentile
- 100%
- References
- 328
Authors
5- XYXiaoyi Yuan
The University of Texas Health Science Center, The University of Texas Health Science Center at Houston
- WRWei Ruan
Central South University, Second Xiangya Hospital of Central South University, The University of Texas Health Science Center, The University of Texas Health Science Center at Houston
- BJBentley J. Bobrow
The University of Texas Health Science Center at Houston
- PCPeter Carmeliet
Khalifa University of Science and Technology, Aarhus University, VIB-KU Leuven Center for Cancer Biology, KU Leuven
- HKHolger K. EltzschigCorresponding
Outcomes Research Consortium, The University of Texas Health Science Center, The University of Texas Health Science Center at Houston
Topics & keywords
- Hypoxia (environmental)
- Hypoxia-inducible factors
- Pharmacology
- Medicine
- Computational biology
- Biology
- Chemistry
- Gene