reviewNature GeneticsDec 28, 2023HYBRID OA

Multi-ancestry genome-wide association meta-analysis of Parkinson’s disease

JJJonggeol Jeffrey KimDVDan VitaleDVDiego Véliz OtaniMMMichelle Mulan LianKHKarl Heilbron

National Institutes of Health · Queen Mary University of London · +164 more institutions

PubMed
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Abstract

Although over 90 independent risk variants have been identified for Parkinson's disease using genome-wide association studies, most studies have been performed in just one population at a time. Here we performed a large-scale multi-ancestry meta-analysis of Parkinson's disease with 49,049 cases, 18,785 proxy cases and 2,458,063 controls including individuals of European, East Asian, Latin American and African ancestry. In a meta-analysis, we identified 78 independent genome-wide significant loci, including 12 potentially novel loci (MTF2, PIK3CA, ADD1, SYBU, IRS2, USP8, PIGL, FASN, MYLK2, USP25, EP300 and PPP6R2) and fine-mapped 6 putative causal variants at 6 known PD loci. By combining our results with…

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247
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300

Topics & keywords

Topics
Keywords
  • Biology
  • Genome-wide association study
  • Genetic association
  • Expression quantitative trait loci
  • Genetics
  • Meta-analysis
  • Disease
  • Population
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