Mitochondrial-derived vesicles in metabolism, disease, and aging

Mitochondria are central hubs of cellular metabolism and are tightly connected to signaling pathways. The dynamic plasticity of mitochondria to fuse, divide, and contact other organelles to flux metabolites is central to their function. To ensure bona fide functionality and signaling interconnectivity, diverse molecular mechanisms evolved. An ancient and long-overlooked mechanism is the generation of mitochondrial-derived vesicles (MDVs) that shuttle selected mitochondrial cargoes to target organelles. Just recently, we gained significant insight into the mechanisms and functions of MDV transport, ranging from their role in mitochondrial quality control to immune signaling, thus demonstrating unexpected and…

• AV
  Alexander von Humboldt-Stiftung
• AS
  Aligning Science Across Parkinson’s
• CR
  Canada Research Chairs
• CI
  Canadian Institutes of Health Research