Histone lactylation couples cellular metabolism with developmental gene regulatory networks
Boston Children's Hospital · Harvard University · +3 more institutions
Abstract
Embryonic cells exhibit diverse metabolic states. Recent studies have demonstrated that metabolic reprogramming drives changes in cell identity by affecting gene expression. However, the connection between cellular metabolism and gene expression remains poorly understood. Here we report that glycolysis-regulated histone lactylation couples the metabolic state of embryonic cells with chromatin organization and gene regulatory network (GRN) activation. We found that lactylation marks genomic regions of glycolytic embryonic tissues, like the neural crest (NC) and pre-somitic mesoderm. Histone lactylation occurs in the loci of NC genes as these cells upregulate glycolysis. This process promotes the accessibility…
Citation impact
- FWCI
- 29.12
- Percentile
- 100%
- References
- 61
Authors
3- FMFjodor MerkuriCorresponding
Boston Children's Hospital, Harvard University, Cornell University, Center for Systems Biology
- MRMegan Rothstein
Boston Children's Hospital, Harvard University, Cornell University, Center for Systems Biology
- MSMarcos Simões-Costa
Boston Children's Hospital, Harvard University, Cornell University, Boston Children's Museum, Center for Systems Biology
Topics & keywords
- Biology
- Enhancer
- Cell biology
- Epigenetics
- Histone
- Chromatin
- Regulation of gene expression
- Embryonic stem cell