A natural biogenic nanozyme for scavenging superoxide radicals
Chinese Academy of Sciences · Institute of Biophysics · +5 more institutions
Abstract
Biominerals, the inorganic minerals of organisms, are known mainly for their physical property-related functions in modern living organisms. Our recent discovery of the enzyme-like activities of nanomaterials, coined as nanozyme, inspires the hypothesis that nano-biominerals might function as enzyme-like catalyzers in cells. Here we report that the iron cores of biogenic ferritins act as natural nanozymes to scavenge superoxide radicals. Through analyzing eighteen representative ferritins from three living kingdoms, we find that the iron core of prokaryote ferritin possesses higher superoxide-diminishing activity than that of eukaryotes. Further investigation reveals that the differences in catalytic…
Citation impact
- FWCI
- 14.21
- Percentile
- 100%
- References
- 79
Authors
10- LMLong Ma
Chinese Academy of Sciences, Institute of Biophysics, University of Chinese Academy of Sciences
- JZJia‐Jia Zheng
National Center for Nanoscience and Technology
- NZNing Zhou
Chinese Academy of Sciences, Institute of Biophysics
- RZRuofei Zhang
Chinese Academy of Sciences, Institute of Biophysics
- LFLong Fang
Chinese Academy of Sciences, Institute of Biophysics, University of Chinese Academy of Sciences
Topics & keywords
- Superoxide
- Radical
- Scavenging
- Chemistry
- Environmental chemistry
- Natural (archaeology)
- Biochemistry
- Biology
Funding
- NNNational Natural Science Foundation of ChinaAwards: 81930050, 22121003, 82122037
- CAChinese Academy of SciencesAwards: JCTD-2020-08, YSBR-089
- YIYouth Innovation Promotion Association of the Chinese Academy of SciencesAward: 2019093
- NKNational Key Research and Development Program of ChinaAward: 2021YFC2102900
- BSBeijing Synchrotron Radiation Facility