Polymeric nanoparticles (PNPs) for oral delivery of insulin
Shihezi University · University of Balochistan · +2 more institutions
Abstract
Successful oral insulin administration can considerably enhance the quality of life (QOL) of diabetes patients who must frequently take insulin injections. Oral insulin administration, on the other hand, is seriously hampered by gastrointestinal enzymes, wide pH range, mucus and mucosal layers, which limit insulin oral bioavailability to ≤ 2%. Therefore, a large number of technological solutions have been proposed to increase the oral bioavailability of insulin, in which polymeric nanoparticles (PNPs) are highly promising for oral insulin delivery. The recently published research articles chosen for this review are based on applications of PNPs with strong future potential in oral insulin delivery, and do not…
Citation impact
- FWCI
- 18.79
- Percentile
- 100%
- References
- 172
Authors
6Topics & keywords
- Insulin
- Insulin delivery
- Bioavailability
- Medicine
- Nanocarriers
- Oral administration
- Diabetes mellitus
- Pharmacology