A bioactive composite hydrogel dressing that promotes healing of both acute and chronic diabetic skin wounds
China-Japan Friendship Hospital · Chinese People's Liberation Army · +3 more institutions
Abstract
Mesenchymal stem cell derived exosomes (MSC-Exos) demonstrate beneficial effects on wound healing via anti-inflammatory and angiogenic properties. Chitosan (CS) exhibits excellent biocompatibility and accelerates cellular migration, adhesion, and proliferation. The ions released from bioactive glass (BG) and titanium dioxide (TiO2) nanoparticles exhibit sustained angiogenic and antibacterial potency. In this study, CMCS-CEBT hydrogel was synthesized from exosomes encapsulated carboxymethyl chitosan (CMCS), chitosan nanoparticles (CS-NPs), BG, and TiO2 nanoparticles for a preliminary evaluation of its impacts on the treatment of full-thickness skin defects, diabetic wounds, and burn skin injury due to burns. In…
Citation impact
- FWCI
- 29.91
- Percentile
- 100%
- References
- 46
Authors
6- SSShunlai Shang
China-Japan Friendship Hospital, Chinese People's Liberation Army, Chinese PLA General Hospital
- KZKaiting Zhuang
Chinese PLA General Hospital, Chinese People's Liberation Army
- JCJianwen Chen
Chinese PLA General Hospital, Chinese People's Liberation Army
- MZMing Zhang
Beijing Chao-Yang Hospital, Capital Medical University
- SJShimin JiangCorresponding
China-Japan Friendship Hospital
Topics & keywords
- Wound healing
- Biocompatibility
- Chitosan
- Mesenchymal stem cell
- In vivo
- Angiogenesis
- Materials science
- Skin repair
- Good health and well-being