Pathological phenotypes of astrocytes in Alzheimer’s disease

Astrocytes are involved in various processes in the central nervous system (CNS). As the most abundant cell type in the CNS, astrocytes play an essential role in neuronal maintenance and support, synaptic activity, neuronal metabolism, and amyloid-beta (Aβ) clearance. Alzheimer's disease (AD) is a neurodegenerative disorder associated with cognitive and behavioral impairment. The transformation of astrocytes is involved in various neurodegenerative diseases, such as AD. Since astrocytes have functional diversity and morphological and physiological heterogeneity in the CNS, AD-related astrocytes might show various pathological phenotypes during AD. Astrocytes developing pathological phenotypes could contribute…

• NR
  National Research Foundation
• SU
  Soonchunhyang University

  Award: 20210137
• NR
  National Research Foundation of Korea

  Awards: NRF- 2021R1F1A1059133, 2021R1F1A1057801, NRF-2021R1F1A1059133, NRF-2021R1C1C1007810, NRF-2021R1F1A1057801, 2021R1C1C1007810