Modification of immune cell-derived exosomes for enhanced cancer immunotherapy: current advances and therapeutic applications

Cancer immunotherapy has revolutionized the approach to cancer treatment of malignant tumors by harnessing the body's immune system to selectively target cancer cells. Despite remarkable advances, there are still challenges in achieving successful clinical responses. Recent evidence suggests that immune cell-derived exosomes modulate the immune system to generate effective antitumor immune responses, making them a cutting-edge therapeutic strategy. However, natural exosomes are limited in clinical application due to their low drug delivery efficiency and insufficient antitumor capacity. Technological advancements have allowed exosome modifications to magnify their intrinsic functions, load different…

• NR
  National Research Foundation

  Award: 2020M3A9I4039539
• MO
  Ministry of Science, ICT and Future Planning

  Award: 21-DGRIP-01
• NR
  National Research Foundation of Korea

  Awards: 2020M3A9I4039539, 2021R1A5A2021614
• DG
  Daegu Gyeongbuk Institute of Science and Technology

  Award: 21-DGRIP-01
• MO
  Ministry of Science and ICT, South Korea

  Awards: 21-DGRIP-01, 2021R1A5A2021614, 2020M3A9I4039539