Encapsulation and assessment of therapeutic cargo in engineered exosomes: a systematic review
Qingdao University · Weifang Medical University · +6 more institutions
Abstract
Exosomes are nanoscale extracellular vesicles secreted by cells and enclosed by a lipid bilayer membrane containing various biologically active cargoes such as proteins, lipids, and nucleic acids. Engineered exosomes generated through genetic modification of parent cells show promise as drug delivery vehicles, and they have been demonstrated to have great therapeutic potential for treating cancer, cardiovascular, neurological, and immune diseases, but systematic knowledge is lacking regarding optimization of drug loading and assessment of delivery efficacy. This review summarizes current approaches for engineering exosomes and evaluating their drug delivery effects, and current techniques for assessing exosome…
Citation impact
- FWCI
- 25.71
- Percentile
- 100%
- References
- 129
Authors
6- ZCZhen ChenCorresponding
Qingdao University, Weifang Medical University, National Health and Family Planning Commission, Shandong Province Health and Family Planning Commission
- MXMin Xiong
North China University of Science and Technology
- JTJiaqi Tian
Qingdao University, National Health and Family Planning Commission, Shandong Province Health and Family Planning Commission
- DSDandan Song
Qingdao University, National Health and Family Planning Commission, Shandong Province Health and Family Planning Commission
- SDShuyin Duan
Shandong First Medical University
Topics & keywords
- Microvesicles
- Exosome
- Drug delivery
- Biodistribution
- Rational design
- Nanomedicine
- Extracellular vesicle
- Nanotechnology
- Good health and well-being