A Fluorinated BODIPY-Based Zirconium Metal–Organic Framework for  In Vivo  Enhanced Photodynamic Therapy

Chen, Xu; Mendes, Bárbara B.; Zhuang, Yunhui; Conniot, João; Argandona, Sergio Mercado; Melle, Francesca; Sousa, Diana P.; Perl, David; Chivu, Alexandru; Patra, Hirak K.; Shepard, William; Conde, João; Fairen‐Jiménez, David

doi:10.1021/jacs.3c12416

articleJournal of the American Chemical SocietyJan 4, 2024HYBRID OA

A Fluorinated BODIPY-Based Zirconium Metal–Organic Framework for In Vivo Enhanced Photodynamic Therapy

XCXu Chen BBBárbara B. Mendes YZYunhui Zhuang JCJoão Conniot SMSergio Mercado Argandona

Agricultural Development Advisory Service (United Kingdom) · Universidade Nova de Lisboa · +2 more institutions

PubMed

Indexed incrossrefpubmed

Abstract

Photodynamic therapy (PDT), an emergent noninvasive cancer treatment, is largely dependent on the presence of efficient photosensitizers (PSs) and a sufficient oxygen supply. However, the therapeutic efficacy of PSs is greatly compromised by poor solubility, aggregation tendency, and oxygen depletion within solid tumors during PDT in hypoxic microenvironments. Despite the potential of PS-based metal–organic frameworks (MOFs), addressing hypoxia remains challenging. Boron dipyrromethene (BODIPY) chromophores, with excellent photostability, have exhibited great potential in PDT and bioimaging. However, their practical application suffers from limited chemical stability under harsh MOF synthesis conditions.…

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115

total citations

FWCI: 19.30
Percentile: 100%
References: 67

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Topics & keywords

Topics

Keywords

Photodynamic therapy
Chemistry
BODIPY
In vivo
Tumor hypoxia
Metal-organic framework
Hypoxia (environmental)
Biodistribution

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