Multi-ancestry genome-wide association study of major depression aids locus discovery, fine mapping, gene prioritization and causal inference

Meng, Xiangrui; Navoly, Georgina; Giannakopoulou, Olga; Levey, Daniel F.; Koller, Dóra; Pathak, Gita A.; Koen, Nastassja; Lin, Kuang; Adams, Mark J.; Rentería, Miguel E.; Feng, Yanzhe; Gaziano, J. Michael; Stein, Dan J.; Zar, Heather J.; Campbell, Megan L.; Heel, David A. van; Trivedi, Bhavi; Finer, Sarah; McQuillin, Andrew; Bass, Nick; Chundru, V. Kartik; Martin, Hilary C.; Huang, Qin Qin; Valkovskaya, Maria; Chu, C. C.; Kanjira, Susan; Kuo, Po‐Hsiu; Chen, Hsi‐Chung; Tsai, Shih‐Jen; Liu, Yu‐Li; Kendler, Kenneth S.; Peterson, Roseann E.; Cai, Na; Fang, Yu; Sen, Srijan; Scott, Laura J.; Burmeister, Margit; Loos, Ruth J. F.; Preuß, Michael; Actkins, Ky’Era V.; Davis, Lea K.; Uddin, Monica; Wani, Agaz H.; Wildman, Derek E.; Aiello, Allison E.; Ursano, Robert J.; Kessler, Ronald C.; Kanai, Masahiro; Okada, Yukinori; Sakaue, Saori; Rabinowitz, Jill A.; Maher, Brion S.; Uhl, George R.; Eaton, William W.; Cruz-Fuentes, Carlos S.; Martínez-Levy, Gabriela Ariadna; Campos, Adrián I.; Millwood, Iona Y.; Chen, Zhengming; Li, Liming; Wassertheil‐Smoller, Sylvia; Jiang, Yunxuan; Tian, Chao; Martin, Nicholas G.; Mitchell, Brittany L.; Byrne, Enda M.; Awasthi, Swapnil; Coleman, Jonathan R. I.; Ripke, Stephan; Group, PGC-MDD Working; Group, China Kadoorie Biobank Collaborative; Project, BioBank Japan; Sofer, Tamar; Walters, Robin; McIntosh, Andrew M.; Polimanti, Renato; Dunn, Erin C.; Stein, Murray B.; Gelernter, Joel; Lewis, Cathryn M.; Kuchenbaecker, Karoline

doi:10.1038/s41588-023-01596-4

articleNature GeneticsJan 4, 2024HYBRID OA

Multi-ancestry genome-wide association study of major depression aids locus discovery, fine mapping, gene prioritization and causal inference

XMXiangrui Meng GNGeorgina Navoly OGOlga Giannakopoulou DFDaniel F. Levey DKDóra Koller

University College London · Yale University · +52 more institutions

PubMed

Indexed incrossrefpubmed

Abstract

Most genome-wide association studies (GWAS) of major depression (MD) have been conducted in samples of European ancestry. Here we report a multi-ancestry GWAS of MD, adding data from 21 cohorts with 88,316 MD cases and 902,757 controls to previously reported data. This analysis used a range of measures to define MD and included samples of African (36% of effective sample size), East Asian (26%) and South Asian (6%) ancestry and Hispanic/Latin American participants (32%). The multi-ancestry GWAS identified 53 significantly associated novel loci. For loci from GWAS in European ancestry samples, fewer than expected were transferable to other ancestry groups. Fine mapping benefited from additional sample…

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Topics & keywords

Topics

Keywords

Biology
Genome-wide association study
Locus (genetics)
Inference
Causal inference
Genetics
Prioritization
Computational biology

UN Sustainable Development Goals

Good health and well-being

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