ACG Clinical Guideline: Alcohol-Associated Liver Disease

ABSTRACT: Alcohol-associated liver disease (ALD) is the most common cause of advanced hepatic disease and frequent indication for liver transplantation worldwide. With harmful alcohol use as the primary risk factor, increasing alcohol use over the past decade has resulted in rapid growth of the ALD-related healthcare burden. The spectrum of ALD ranges from early asymptomatic liver injury to advanced disease with decompensation and portal hypertension. Compared with those with other etiologies of liver disease, patients with ALD progress faster and more often present at an advanced stage. A unique phenotype of advanced disease is alcohol-associated hepatitis (AH) presenting with rapid onset or worsening of…

• AC
  American College of Gastroenterology
• NI
  National Institutes of Health
• NI
  National Institute on Alcohol Abuse and Alcoholism

  Awards: U01 AA021788, U01 AA021908, R21 AA023273
• NI
  National Institute of Diabetes and Digestive and Kidney Diseases

  Award: K08 DK123381