The role of inflammasomes in human diseases and their potential as therapeutic targets
Capital Medical University · University of British Columbia · +4 more institutions
Abstract
Inflammasomes are large protein complexes that play a major role in sensing inflammatory signals and triggering the innate immune response. Each inflammasome complex has three major components: an upstream sensor molecule that is connected to a downstream effector protein such as caspase-1 through the adapter protein ASC. Inflammasome formation typically occurs in response to infectious agents or cellular damage. The active inflammasome then triggers caspase-1 activation, followed by the secretion of pro-inflammatory cytokines and pyroptotic cell death. Aberrant inflammasome activation and activity contribute to the development of diabetes, cancer, and several cardiovascular and neurodegenerative disorders. As…
Citation impact
- FWCI
- 42.84
- Percentile
- 100%
- References
- 454
Authors
5- JYJing YaoCorresponding
Capital Medical University
- KSKeenan Sterling
University of British Columbia
- ZWZhe Wang
Capital Medical University
- YZYun Zhang
Capital Medical University, Ministry of Education
- WSWeihong Song
University of British Columbia, Capital Medical University, Wenzhou Medical University, National Clinical Research Center for Digestive Diseases, Zhejiang Lab
Topics & keywords
- Inflammasome
- Innate immune system
- AIM2
- Pyroptosis
- Effector
- Disease
- Inflammation
- Biology
- Good health and well-being