Ischemia-reperfusion injury: molecular mechanisms and therapeutic targets

Abstract Ischemia-reperfusion (I/R) injury paradoxically occurs during reperfusion following ischemia, exacerbating the initial tissue damage. The limited understanding of the intricate mechanisms underlying I/R injury hinders the development of effective therapeutic interventions. The Wnt signaling pathway exhibits extensive crosstalk with various other pathways, forming a network system of signaling pathways involved in I/R injury. This review article elucidates the underlying mechanisms involved in Wnt signaling, as well as the complex interplay between Wnt and other pathways, including Notch, phosphatidylinositol 3-kinase/protein kinase B, transforming growth factor-β, nuclear factor kappa, bone…

• UO
  University of Michigan
• UO
  University of Washington
• UO
  University of Texas Southwestern Medical Center
• NN
  National Natural Science Foundation of China

  Awards: 82170255, 82170389, 81700055
• HN
  Hunan Normal University
• GO
  Government of Jiangsu Province
• NS
  Natural Science Foundation of Jiangsu Province

  Award: BK20160229
• JM
  Jining Medical University

  Award: 600791001
• XM
  Xuzhou Medical University

  Awards: D2016021, BK20160229
• CO
  College of Pharmacy, University of Michigan
• UO
  University of California, Los Angeles