A single-cell atlas of the aging mouse ovary

Isola, José V. V.; Ocañas, Sarah R.; Hubbart, Chase R.; Ko, Sung-Hwan; Mondal, Samim Ali; Hense, Jéssica D.; Carter, Hannah N. C.; Schneider, Augusto; Kovats, Susan; Alberola‐Ila, José; Freeman, Willard M.; Stout, Michael B.

doi:10.1038/s43587-023-00552-5

articleNature AgingJan 10, 2024HYBRID OA

A single-cell atlas of the aging mouse ovary

JVJosé V. V. Isola SRSarah R. Ocañas CRChase R. Hubbart SKSung-Hwan Ko SASamim Ali Mondal

Oklahoma Medical Research Foundation · University of Oklahoma Health Sciences Center · +3 more institutions

PubMed

Indexed incrossrefpubmed

Abstract

Ovarian aging leads to diminished fertility, dysregulated endocrine signaling and increased chronic disease burden. These effects begin to emerge long before follicular exhaustion. Female humans experience a sharp decline in fertility around 35 years of age, which corresponds to declines in oocyte quality. Despite a growing body of work, the field lacks a comprehensive cellular map of the transcriptomic changes in the aging mouse ovary to identify early drivers of ovarian decline. To fill this gap we performed single-cell RNA sequencing on ovarian tissue from young (3-month-old) and reproductively aged (9-month-old) mice. Our analysis revealed a doubling of immune cells in the aged ovary, with lymphocyte…

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Topics & keywords

Topics

Keywords

Biology
Ovary
Follicular phase
Immunosenescence
Ovarian follicle
Ovarian reserve
Immune system
Fibrosis

UN Sustainable Development Goals

Good health and well-being

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