Inter-plasmid transfer of antibiotic resistance genes accelerates antibiotic resistance in bacterial pathogens
Nankai University · Kementerian Pendidikan Malaysia · +5 more institutions
Abstract
Antimicrobial resistance is a major threat for public health. Plasmids play a critical role in the spread of antimicrobial resistance via horizontal gene transfer between bacterial species. However, it remains unclear how plasmids originally recruit and assemble various antibiotic resistance genes (ARGs). Here, we track ARG recruitment and assembly in clinically relevant plasmids by combining a systematic analysis of 2420 complete plasmid genomes and experimental validation. Results showed that ARG transfer across plasmids is prevalent, and 87% ARGs were observed to potentially transfer among various plasmids among 8229 plasmid-borne ARGs. Interestingly, recruitment and assembly of ARGs occur mostly among…
Citation impact
- FWCI
- 20.83
- Percentile
- 100%
- References
- 71
Authors
9- XWXiaolong WangCorresponding
Nankai University, Kementerian Pendidikan Malaysia
- HZHanhui Zhang
State Key Laboratory of Pollution Control and Resource Reuse, Nanjing University
- SYShenbo Yu
State Key Laboratory of Pollution Control and Resource Reuse, Nanjing University
- DLDonghang Li
Nankai University
- MRMichael R. Gillings
ARC Centre of Excellence in Synthetic Biology, Macquarie University
Topics & keywords
- Plasmid
- Biology
- Horizontal gene transfer
- Antibiotic resistance
- Microbiology
- Genetics
- Gene
- Antibiotics