articleNatureJan 10, 2024HYBRID OA

The selection landscape and genetic legacy of ancient Eurasians

EKEvan K. Irving-PeaseARAlba Refoyo-MartínezWBWilliam BarrieAIAndrés IngasonAPAlice Pearson

University of Copenhagen · Lundbeck Foundation · +24 more institutions

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Abstract

Abstract The Holocene (beginning around 12,000 years ago) encompassed some of the most significant changes in human evolution, with far-reaching consequences for the dietary, physical and mental health of present-day populations. Using a dataset of more than 1,600 imputed ancient genomes 1 , we modelled the selection landscape during the transition from hunting and gathering, to farming and pastoralism across West Eurasia. We identify key selection signals related to metabolism, including that selection at the FADS cluster began earlier than previously reported and that selection near the LCT locus predates the emergence of the lactase persistence allele by thousands of years. We also find strong selection in…

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Topics & keywords

Topics
Keywords
  • Selection (genetic algorithm)
  • Evolutionary biology
  • Biology
  • Archaeology
  • Geography
  • Computer science
  • Artificial intelligence
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