Insights for precision oncology from the integration of genomic and clinical data of 13,880 tumors from the 100,000 Genomes Cancer Programme

The Cancer Programme of the 100,000 Genomes Project was an initiative to provide whole-genome sequencing (WGS) for patients with cancer, evaluating opportunities for precision cancer care within the UK National Healthcare System (NHS). Genomics England, alongside NHS England, analyzed WGS data from 13,880 solid tumors spanning 33 cancer types, integrating genomic data with real-world treatment and outcome data, within a secure Research Environment. Incidence of somatic mutations in genes recommended for standard-of-care testing varied across cancer types. For instance, in glioblastoma multiforme, small variants were present in 94% of cases and copy number aberrations in at least one gene in 58% of cases, while…

• WT
  Wellcome Trust
• CR
  Cancer Research UK

  Awards: C17422/A25154., C1298/A8362, C17422/A25154
• NI
  National Institute for Health and Care Research
• DO
  Department of Health and Social Care
• UO
  University of Cambridge
• IC
  Imperial College London
• UC
  University College London
• UO
  University of Oxford
• CU
  Cambridge University Hospitals
• GO
  Great Ormond Street Hospital for Children
• OU
  Oxford University Hospitals NHS Foundation Trust
• MR
  Medical Research Council

  Awards: MC_EX_MR/M009203/1, MC_PC_14089