Intratumoural microbiota: a new frontier in cancer development and therapy

Human microorganisms, including bacteria, fungi, and viruses, play key roles in several physiological and pathological processes. Some studies discovered that tumour tissues once considered sterile actually host a variety of microorganisms, which have been confirmed to be closely related to oncogenesis. The concept of intratumoural microbiota was subsequently proposed. Microbiota could colonise tumour tissues through mucosal destruction, adjacent tissue migration, and hematogenic invasion and affect the biological behaviour of tumours as an important part of the tumour microenvironment. Mechanistic studies have demonstrated that intratumoural microbiota potentially promote the initiation and progression of…

• NN
  National Natural Science Foundation of China

  Awards: 82102496, 82330003, 82001988, 82070099
• TU
  Tongji University
• ZU
  Zhejiang University
• NS
  National Science and Technology Major Project

  Award: 2022YFF1203300
• WU
  Wuhan Union Hospital