articleNature ImmunologyJan 11, 2024HYBRID OA

Long COVID manifests with T cell dysregulation, inflammation and an uncoordinated adaptive immune response to SARS-CoV-2

KYKailin YinMJMichael J. PelusoXLXiaoyu LuoRTReuben ThomasMSMin‐Gyoung Shin

Gladstone Institutes · University of California, San Francisco · +2 more institutions

PubMed
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Abstract

Abstract Long COVID (LC) occurs after at least 10% of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infections, yet its etiology remains poorly understood. We used ‘omic” assays and serology to deeply characterize the global and SARS-CoV-2-specific immunity in the blood of individuals with clear LC and non-LC clinical trajectories, 8 months postinfection. We found that LC individuals exhibited systemic inflammation and immune dysregulation. This was evidenced by global differences in T cell subset distribution implying ongoing immune responses, as well as by sex-specific perturbations in cytolytic subsets. LC individuals displayed increased frequencies of CD4 + T cells poised to migrate to…

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Topics & keywords

Topics
Keywords
  • Immune system
  • Immunology
  • Inflammation
  • Acquired immune system
  • Immune dysregulation
  • CD8
  • Immunity
  • Antibody
UN Sustainable Development Goals
  • Good health and well-being
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