Multi-omics analysis of innate and adaptive responses to BCG vaccination reveals epigenetic cell states that predict trained immunity
Radboud University Medical Center · Radboud University Nijmegen · +12 more institutions
Abstract
Immune responses are tightly regulated yet highly variable between individuals. To investigate human population variation of trained immunity, we immunized healthy individuals with Bacillus Calmette-Guérin (BCG). This live-attenuated vaccine induces not only an adaptive immune response against tuberculosis but also triggers innate immune activation and memory that are indicative of trained immunity. We established personal immune profiles and chromatin accessibility maps over a 90-day time course of BCG vaccination in 323 individuals. Our analysis uncovered genetic and epigenetic predictors of baseline immunity and immune response. BCG vaccination enhanced the innate immune response specifically in individuals…
Citation impact
- FWCI
- 23.13
- Percentile
- 100%
- References
- 114
Authors
25- SJSimone J.C.F.M. Moorlag
Radboud University Medical Center, Radboud University Nijmegen
- LFLukas Folkman
Medical University of Vienna, Austrian Research Institute for Artificial Intelligence, Austrian Academy of Sciences, CeMM Research Center for Molecular Medicine
- RTRob ter Horst
Austrian Academy of Sciences, CeMM Research Center for Molecular Medicine
- TKThomas Krausgruber
Austrian Academy of Sciences, Austrian Research Institute for Artificial Intelligence, Medical University of Vienna, CeMM Research Center for Molecular Medicine
- DBDaniele Barreca
Austrian Academy of Sciences, CeMM Research Center for Molecular Medicine
Topics & keywords
- Immune system
- Immunity
- Biology
- Innate immune system
- Vaccination
- Acquired immune system
- Immunology
- Epigenetics
- Good health and well-being