articleNature Ecology & EvolutionJan 12, 2024HYBRID OA

Hagfish genome elucidates vertebrate whole-genome duplication events and their evolutionary consequences

DYDaqi YuYRYandong RenMUMasahiro UesakaAJAlan J. S. BeavanMMMatthieu Muffato

Chinese Academy of Sciences · University of Chinese Academy of Sciences · +37 more institutions

PubMed
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Abstract

Polyploidy or whole-genome duplication (WGD) is a major event that drastically reshapes genome architecture and is often assumed to be causally associated with organismal innovations and radiations. The 2R hypothesis suggests that two WGD events (1R and 2R) occurred during early vertebrate evolution. However, the timing of the 2R event relative to the divergence of gnathostomes (jawed vertebrates) and cyclostomes (jawless hagfishes and lampreys) is unresolved and whether these WGD events underlie vertebrate phenotypic diversification remains elusive. Here we present the genome of the inshore hagfish, Eptatretus burgeri. Through comparative analysis with lamprey and gnathostome genomes, we reconstruct the early…

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Topics & keywords

Topics
Keywords
  • Hagfish
  • Genome
  • Gene duplication
  • Biology
  • Vertebrate
  • Evolutionary biology
  • Genetics
  • Gene
UN Sustainable Development Goals
  • Life below water
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