Role of reactive oxygen species in ultraviolet-induced photodamage of the skin
Shanghai Jiao Tong University · Shanghai Sixth People's Hospital · +2 more institutions
Abstract
•-) and hydroxyl groups (OH·), are short-lived molecules containing unpaired electrons. Intracellular ROS are believed to be mainly produced by the mitochondria and NADPH oxidase (NOX) and can be associated with various physiological processes, such as proliferation, cell signaling, and oxygen homeostasis. In recent years, many studies have indicated that ROS play crucial roles in regulating ultraviolet (UV)-induced photodamage of the skin, including exogenous aging, which accounts for 80% of aging. However, to the best of our knowledge, the detailed signaling pathways, especially those related to the mechanisms underlying apoptosis in which ROS are involved have not been reviewed previously. In this review,…
Citation impact
- FWCI
- 90.45
- Percentile
- 100%
- References
- 86
Authors
4- MWMin WeiCorresponding
Shanghai Jiao Tong University, Shanghai Sixth People's Hospital
- XHXin He
Capital Medical University, Beijing Chao-Yang Hospital, Capital Medical University
- NLNa Liu
Shanghai Jiao Tong University, Shanghai Sixth People's Hospital
- HDHui Deng
Shanghai Jiao Tong University, Shanghai Sixth People's Hospital
Topics & keywords
- Reactive oxygen species
- NADPH oxidase
- Cell biology
- Mitochondrion
- Intracellular
- Superoxide
- Apoptosis
- Cell signaling