articleCell Death and DiseaseJan 13, 2024GOLD OA

Amino acid metabolism in tumor biology and therapy

JCJie ChenLCLikun CuiSLShaoteng LuSXSheng Xu

Second Military Medical University · Shanghai Cell Therapy Research Institute

PubMed
Indexed incrossrefdoajpubmed

Abstract

Amino acid metabolism plays important roles in tumor biology and tumor therapy. Accumulating evidence has shown that amino acids contribute to tumorigenesis and tumor immunity by acting as nutrients, signaling molecules, and could also regulate gene transcription and epigenetic modification. Therefore, targeting amino acid metabolism will provide new ideas for tumor treatment and become an important therapeutic approach after surgery, radiotherapy, and chemotherapy. In this review, we systematically summarize the recent progress of amino acid metabolism in malignancy and their interaction with signal pathways as well as their effect on tumor microenvironment and epigenetic modification. Collectively, we also…

Citation impact

216
total citations
FWCI
56.44
Percentile
100%
References
236
Citations per year

Authors

4

Topics & keywords

Topics
Keywords
  • Epigenetics
  • Amino acid
  • Biology
  • Metabolism
  • Tumor microenvironment
  • Carcinogenesis
  • Signal transduction
  • Amino acid metabolism
UN Sustainable Development Goals
  • Good health and well-being
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