articleJournal of Biomedical ScienceJan 14, 2024DIAMOND OA

Scaffold-based 3D cell culture models in cancer research

American University of Sharjah · Brigham Young University

PubMed
Indexed incrossrefdoajpubmed

Abstract

Three-dimensional (3D) cell cultures have emerged as valuable tools in cancer research, offering significant advantages over traditional two-dimensional (2D) cell culture systems. In 3D cell cultures, cancer cells are grown in an environment that more closely mimics the 3D architecture and complexity of in vivo tumors. This approach has revolutionized cancer research by providing a more accurate representation of the tumor microenvironment (TME) and enabling the study of tumor behavior and response to therapies in a more physiologically relevant context. One of the key benefits of 3D cell culture in cancer research is the ability to recapitulate the complex interactions between cancer cells and their…

Citation impact

264
total citations
FWCI
44.09
Percentile
100%
References
191
Citations per year

Authors

3

Topics & keywords

Keywords
  • Stromal cell
  • 3D cell culture
  • Cancer cell
  • Tumor microenvironment
  • Context (archaeology)
  • Cancer
  • Scaffold
  • Biology
No related works found for this paper.

Funding