Cancer epigenetics: from laboratory studies and clinical trials to precision medicine

Abstract Epigenetic dysregulation is a common feature of a myriad of human diseases, particularly cancer. Defining the epigenetic defects associated with malignant tumors has become a focus of cancer research resulting in the gradual elucidation of cancer cell epigenetic regulation. In fact, most stages of tumor progression, including tumorigenesis, promotion, progression, and recurrence are accompanied by epigenetic alterations, some of which can be reversed by epigenetic drugs. The main objective of epigenetic therapy in the era of personalized precision medicine is to detect cancer biomarkers to improve risk assessment, diagnosis, and targeted treatment interventions. Rapid technological advancements…

• NN
  National Natural Science Foundation of China

  Award: 32100561
• N
  Nature
• BA
  Basic and Applied Basic Research Foundation of Guangdong Province

  Award: 2020A1515110057