Urease-powered nanobots for radionuclide bladder cancer therapy

Simó, Cristina; Serra-Casablancas, Meritxell; Hortelão, Ana C.; Carlo, Valerio Di; Guallar-Garrido, Sandra; Plaza‐García, Sandra; Rabanal, Rosa M.; Ramos‐Cabrer, Pedro; Yagüe, Balbino; Aguado, Laura; Bardia, Lídia; Tosi, Sébastien; Gómez‐Vallejo, Vanessa; Martín, Abraham; Patiño, Tania; Julián, Esther; Colombelli, Julien; Llop, Jordi; Sánchez, Samuel

doi:10.1038/s41565-023-01577-y

articleNature NanotechnologyJan 15, 2024HYBRID OA

Urease-powered nanobots for radionuclide bladder cancer therapy

CSCristina Simó MSMeritxell Serra-Casablancas ACAna C. Hortelão VDValerio Di Carlo SGSandra Guallar-Garrido

CIC biomaGUNE · Mallinckrodt (United States) · +10 more institutions

PubMed

Indexed incrossrefpubmed

Abstract

Bladder cancer treatment via intravesical drug administration achieves reasonable survival rates but suffers from low therapeutic efficacy. To address the latter, self-propelled nanoparticles or nanobots have been proposed, taking advantage of their enhanced diffusion and mixing capabilities in urine when compared with conventional drugs or passive nanoparticles. However, the translational capabilities of nanobots in treating bladder cancer are underexplored. Here, we tested radiolabelled mesoporous silica-based urease-powered nanobots in an orthotopic mouse model of bladder cancer. In vivo and ex vivo results demonstrated enhanced nanobot accumulation at the tumour site, with an eightfold increase revealed by…

Citation impact

159

total citations

FWCI: 78.33
Percentile: 100%
References: 55

Citations per year

Authors

19

Topics & keywords

Topics

Keywords

In vivo
Ex vivo
Bladder cancer
Medicine
Cancer
Pathology
Biomedical engineering
Nuclear medicine

UN Sustainable Development Goals

Good health and well-being

No related works found for this paper.