Current Advances in Photodynamic Therapy (PDT) and the Future Potential of PDT-Combinatorial Cancer Therapies
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Abstract
Photodynamic therapy (PDT) is a two-stage treatment that implies the use of light energy, oxygen, and light-activated compounds (photosensitizers) to elicit cancerous and precancerous cell death after light activation (phototoxicity). The biophysical, bioengineering aspects and its combinations with other strategies are highlighted in this review, both conceptually and as they are currently applied clinically. We further explore the recent advancements of PDT with the use of nanotechnology, including quantum dots as innovative photosensitizers or energy donors as well as the combination of PDT with radiotherapy and immunotherapy as future promising cancer treatments. Finally, we emphasize the potential…
Citation impact
213
total citations
- FWCI
- 35.78
- Percentile
- 100%
- References
- 134
Citations per year
Authors
2Topics & keywords
Topics
Keywords
- Photodynamic therapy
- Phototoxicity
- Cancer
- Radiation therapy
- Cancer therapy
- Medicine
- Cancer treatment
- Cancer research
UN Sustainable Development Goals
- Good health and well-being
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Funding
- ECEuropean CommissionAwards: 10.13039/501100011033, 13039/501100011033, 501100011033, AEI/10.13039/501100011033, MCIN/AEI/10.13039/501100011033
- EREuropean Regional Development FundAwards: MCIN/AEI/10, MCIN/AEI/10.13039/501100011033, 10.13039/501100011033, 13039/501100011033, AEI/10.13039/501100011033, 501100011033
- AEAgencia Estatal de InvestigaciónAwards: AEI/10.13039/501100011033, 501100011033, 10.13039/501100011033, MCIN/AEI/10.13039/501100011033, 13039, 10.13039, AEI/10, 13039/501100011033, AEI/10.