reviewBrainJan 16, 2024HYBRID OA

Imaging chronic active lesions in multiple sclerosis: a consensus statement

FBFrancesca BagnatoPSPascal SatiCCChristopher C. HemondCEColm ElliottSASusan A. Gauthier

VA Tennessee Valley Healthcare System · Nashville VA Medical Center · +34 more institutions

PubMed
Indexed incrossrefpubmed

Abstract

Chronic active lesions (CAL) are an important manifestation of chronic inflammation in multiple sclerosis and have implications for non-relapsing biological progression. In recent years, the discovery of innovative MRI and PET-derived biomarkers has made it possible to detect CAL, and to some extent quantify them, in the brain of persons with multiple sclerosis, in vivo. Paramagnetic rim lesions on susceptibility-sensitive MRI sequences, MRI-defined slowly expanding lesions on T1-weighted and T2-weighted scans, and 18-kDa translocator protein-positive lesions on PET are promising candidate biomarkers of CAL. While partially overlapping, these biomarkers do not have equivalent sensitivity and specificity to…

Citation impact

162
total citations
FWCI
60.91
Percentile
100%
References
190
Citations per year

Authors

21

Topics & keywords

Topics
Keywords
  • Multiple sclerosis
  • Consensus conference
  • Medicine
  • Statement (logic)
  • Pathology
  • Psychiatry
  • Internal medicine
  • Political science
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