Lung microbiome: new insights into the pathogenesis of respiratory diseases

The lungs were long thought to be sterile until technical advances uncovered the presence of the lung microbial community. The microbiome of healthy lungs is mainly derived from the upper respiratory tract (URT) microbiome but also has its own characteristic flora. The selection mechanisms in the lung, including clearance by coughing, pulmonary macrophages, the oscillation of respiratory cilia, and bacterial inhibition by alveolar surfactant, keep the microbiome transient and mobile, which is different from the microbiome in other organs. The pulmonary bacteriome has been intensively studied recently, but relatively little research has focused on the mycobiome and virome. This up-to-date review retrospectively…

• NN
  National Natural Science Foundation of China

  Awards: No.82072999, 82273320, 82241049, 82273320, No.82241049, 81922042, 82172285, 82172285, 82072999, 81922042
• SU
  Sichuan University

  Awards: ZYYC21001, 2022SCUH0029
• S
  Servier
• WC
  West China Hospital, Sichuan University

  Award: ZYYC21001