Differentiation of hypervirulent and classical Klebsiella pneumoniae with acquired drug resistance

Hypervirulent Klebsiella pneumoniae (hvKp) is a concerning pathogen that can cause life-threatening infections in otherwise healthy individuals. Importantly, although strains of hvKp have been acquiring antimicrobial resistance, the effect on virulence is unclear. Therefore, it is of critical importance to determine whether a given antimicrobial resistant K. pneumoniae isolate is hypervirulent. This report determined which combination of genotypic and phenotypic markers could most accurately identify hvKp strains with acquired resistance. Both logistic regression and a machine-learning prediction model demonstrated that biomarker count alone was the strongest predictor. The presence of all five of the…

• UD
  U.S. Department of Defense
• UD
  U.S. Department of Veterans Affairs

  Award: I01 BX004677-01
• VA
  Veterans Administration Medical Center

  Award: BX004677-01
• NI
  National Institutes of Health

  Award: 1R21AI141826-01A1
• CF
  Centers for Disease Control and Prevention
• AF
  Agency for Toxic Substances and Disease Registry
• UA
  U.S. Army Medical Command