A gut microbiota-bile acid axis promotes intestinal homeostasis upon aspirin-mediated damage

Aspirin-related gastrointestinal damage is of growing concern. Aspirin use modulates the gut microbiota and associated metabolites, such as bile acids (BAs), but how this impacts intestinal homeostasis remains unclear. Herein, using clinical cohorts and aspirin-treated mice, we identified an intestinal microbe, Parabacteroides goldsteinii, whose growth is suppressed by aspirin. Mice supplemented with P. goldsteinii or its BA metabolite, 7-keto-lithocholic acid (7-keto-LCA), showed reduced aspirin-mediated damage of the intestinal niche and gut barrier, effects that were lost with a P. goldsteinii hdhA mutant unable to generate 7-keto-LCA. Specifically, 7-keto-LCA promotes repair of the intestinal epithelium by…

• NS
  National Science Foundation
• NN
  National Natural Science Foundation of China

  Awards: 82370458, 82000474
• XJ
  Xi’an Jiaotong University
• NS
  Natural Science Foundation of Shaanxi Province

  Awards: 2020JM-383, 2021KJXX
• NK
  National Key Research and Development Program of China

  Awards: 2021YFA0805403, 2021YFA1301201
• NC
  National Cancer Institute