articleCell stem cellJan 17, 2024HYBRID OA

SARS-CoV-2 infection causes dopaminergic neuron senescence

LYLiuliu YangTWTae Wan KimYHYuling HanMSManoj S. NairOHOliver Harschnitz

Cornell University · Genomic Health (United States) · +8 more institutions

PubMed
Indexed incrossrefpubmed

Abstract

COVID-19 patients commonly present with signs of central nervous system and/or peripheral nervous system dysfunction. Here, we show that midbrain dopamine (DA) neurons derived from human pluripotent stem cells (hPSCs) are selectively susceptible and permissive to severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection. SARS-CoV-2 infection of DA neurons triggers an inflammatory and cellular senescence response. High-throughput screening in hPSC-derived DA neurons identified several FDA-approved drugs that can rescue the cellular senescence phenotype by preventing SARS-CoV-2 infection. We also identified the inflammatory and cellular senescence signature and low levels of SARS-CoV-2 transcripts…

Citation impact

112
total citations
FWCI
32.60
Percentile
100%
References
49
Citations per year

Authors

28

Topics & keywords

Topics
Keywords
  • Biology
  • Induced pluripotent stem cell
  • Senescence
  • Substantia nigra
  • Dopaminergic
  • Neuroprotection
  • Dopamine
  • Neuroscience
UN Sustainable Development Goals
  • Good health and well-being
No related works found for this paper.

Funding