cAMP-PKA/EPAC signaling and cancer: the interplay in tumor microenvironment
Sichuan University · State Key Laboratory of Biotherapy · +2 more institutions
Abstract
Cancer is a complex disease resulting from abnormal cell growth that is induced by a number of genetic and environmental factors. The tumor microenvironment (TME), which involves extracellular matrix, cancer-associated fibroblasts (CAF), tumor-infiltrating immune cells and angiogenesis, plays a critical role in tumor progression. Cyclic adenosine monophosphate (cAMP) is a second messenger that has pleiotropic effects on the TME. The downstream effectors of cAMP include cAMP-dependent protein kinase (PKA), exchange protein activated by cAMP (EPAC) and ion channels. While cAMP can activate PKA or EPAC and promote cancer cell growth, it can also inhibit cell proliferation and survival in context- and cancer…
Citation impact
- FWCI
- 24.27
- Percentile
- 100%
- References
- 426
Authors
7- HZHongying Zhang
Sichuan University, State Key Laboratory of Biotherapy
- YLYongliang Liu
Sichuan University, State Key Laboratory of Biotherapy
- JLJieya Liu
Sichuan University, State Key Laboratory of Biotherapy
- JCJinzhu Chen
Sichuan University, State Key Laboratory of Biotherapy
- JWJiao Wang
Chengdu University of Traditional Chinese Medicine
Topics & keywords
- Hematology
- Tumor microenvironment
- Cancer
- Internal medicine
- Cancer research
- Medicine
- Oncology