Cancer-associated fibroblast phenotypes are associated with patient outcome in non-small cell lung cancer
University of Zurich · ETH Zurich · +2 more institutions
Abstract
Despite advances in treatment, lung cancer survival rates remain low. A better understanding of the cellular heterogeneity and interplay of cancer-associated fibroblasts (CAFs) within the tumor microenvironment will support the development of personalized therapies. We report a spatially resolved single-cell imaging mass cytometry (IMC) analysis of CAFs in a non-small cell lung cancer cohort of 1,070 patients. We identify four prognostic patient groups based on 11 CAF phenotypes with distinct spatial distributions and show that CAFs are independent prognostic factors for patient survival. The presence of tumor-like CAFs is strongly correlated with poor prognosis. In contrast, inflammatory CAFs and…
Citation impact
- FWCI
- 53.50
- Percentile
- 100%
- References
- 82
Authors
7Topics & keywords
- Tumor microenvironment
- Cancer-Associated Fibroblasts
- Lung cancer
- Phenotype
- Mass cytometry
- Stromal cell
- Cancer research
- Medicine
- Good health and well-being
Funding
- CRCancer Research UK
- ECEuropean CommissionAwards: 177208, 866074
- SNSchweizerischer Nationalfonds zur Förderung der Wissenschaftlichen ForschungAwards: 177208, UC4 DK108132, 310030_205007, 316030_213512
- UZUniversität Zürich
- NINational Institutes of HealthAwards: UC4 DK108132, DK108132
- EREuropean Research Council
- HEH2020 European Research CouncilAward: 866074