articleNature CommunicationsFeb 16, 2024GOLD OA

A microfluidic platform integrating functional vascularized organoids-on-chip

CQClément QuintardETEmily TubbsGJGustav JonssonJJJie JiaoJWJun Wang

University of British Columbia · Commissariat à l'Énergie Atomique et aux Énergies Alternatives · +12 more institutions

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Abstract

The development of vascular networks in microfluidic chips is crucial for the long-term culture of three-dimensional cell aggregates such as spheroids, organoids, tumoroids, or tissue explants. Despite rapid advancement in microvascular network systems and organoid technologies, vascularizing organoids-on-chips remains a challenge in tissue engineering. Most existing microfluidic devices poorly reflect the complexity of in vivo flows and require complex technical set-ups. Considering these constraints, we develop a platform to establish and monitor the formation of endothelial networks around mesenchymal and pancreatic islet spheroids, as well as blood vessel organoids generated from pluripotent stem cells,…

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Topics & keywords

Topics
Keywords
  • Organoid
  • Microfluidics
  • Spheroid
  • Organ-on-a-chip
  • Cell biology
  • Induced pluripotent stem cell
  • Vascular network
  • Tissue engineering
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