Unravelling cell type-specific responses to Parkinson’s Disease at single cell resolution
VIB-KU Leuven Center for Brain & Disease Research · University of Cambridge · +9 more institutions
Abstract
Parkinson's Disease (PD) is the second most common neurodegenerative disorder. The pathological hallmark of PD is loss of dopaminergic neurons and the presence of aggregated α-synuclein, primarily in the substantia nigra pars compacta (SNpc) of the midbrain. However, the molecular mechanisms that underlie the pathology in different cell types is not currently understood. Here, we present a single nucleus transcriptome analysis of human post-mortem SNpc obtained from 15 sporadic Parkinson's Disease (PD) cases and 14 Controls. Our dataset comprises ∼84K nuclei, representing all major cell types of the brain, allowing us to obtain a transcriptome-level characterization of these cell types. Importantly, we…
Citation impact
- FWCI
- 22.35
- Percentile
- 100%
- References
- 70
Authors
17- AMAraks Martirosyan
VIB-KU Leuven Center for Brain & Disease Research
- RARizwan Ansari
University of Cambridge, UK Dementia Research Institute
- FPFrancisco Pestana
VIB-KU Leuven Center for Brain & Disease Research
- KHKatja Hebestreit
- HGHayk Gasparyan
Yerevan State University, National Academy of Sciences of Armenia
Topics & keywords
- Pars compacta
- Substantia nigra
- Biology
- Cell type
- Neuroscience
- Transcriptome
- Neuromelanin
- Astrocyte