reviewMicroorganismsJan 22, 2024GOLD OA

Helicobacter pylori: A Contemporary Perspective on Pathogenesis, Diagnosis and Treatment Strategies

AAAsghar AliKIKhalid I. AlHussaini

Jamia Hamdard · Imam Mohammad ibn Saud Islamic University

PubMed
Indexed incrossrefdoajpubmed

Abstract

Helicobacter pylori (H. pylori) is a Gram-negative bacterium that colonizes the gastric mucosa and is associated with various gastrointestinal disorders. H. pylori is a pervasive pathogen, infecting nearly 50% of the world’s population, and presents a substantial concern due to its link with gastric cancer, ranking as the third most common cause of global cancer-related mortality. This review article provides an updated and comprehensive overview of the current understanding of H. pylori infection, focusing on its pathogenesis, diagnosis, and treatment strategies. The intricate mechanisms underlying its pathogenesis, including the virulence factors and host interactions, are discussed in detail. The diagnostic…

Citation impact

126
total citations
FWCI
64.54
Percentile
100%
References
159
Citations per year

Authors

2

Topics & keywords

Topics
Keywords
  • Helicobacter pylori
  • Cancer
  • Pathogenesis
  • Intensive care medicine
  • Medicine
  • Mechanism (biology)
  • Immunology
  • Internal medicine
UN Sustainable Development Goals
  • Good health and well-being
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Funding