Guidelines for the diagnosis and management of adult aplastic anaemia: A British Society for Haematology Guideline
King's College London · King's College Hospital NHS Foundation Trust · +20 more institutions
Abstract
Pancytopenia with hypocellular bone marrow is the hallmark of aplastic anaemia (AA) and the diagnosis is confirmed after careful evaluation, following exclusion of alternate diagnosis including hypoplastic myelodysplastic syndromes. Emerging use of molecular cyto-genomics is helpful in delineating immune mediated AA from inherited bone marrow failures (IBMF). Camitta criteria is used to assess disease severity, which along with age and availability of human leucocyte antigen compatible donor are determinants for therapeutic decisions. Supportive care with blood and platelet transfusion support, along with anti-microbial prophylaxis and prompt management of opportunistic infections remain key throughout the…
Citation impact
- FWCI
- 45.96
- Percentile
- 100%
- References
- 143
Authors
17- AKAustin KulasekararajCorresponding
King's College London, King's College Hospital NHS Foundation Trust
- JCJamie Cavenagh
St Bartholomew's Hospital, Barts Health NHS Trust
- IDInderjeet Dokal
Queen Mary University of London, Barts Health NHS Trust
- TFTheodora Foukaneli
NHS Blood and Transplant, Cambridge University Hospitals NHS Foundation Trust, Addenbrooke's Hospital
- SGShreyans Gandhi
King's College London, King's College Hospital NHS Foundation Trust
Topics & keywords
- Medicine
- Pancytopenia
- Guideline
- Hematology
- Eltrombopag
- Bone marrow failure
- Disease
- Intensive care medicine
- Good health and well-being