A review of the pathophysiological mechanisms of doxorubicin-induced cardiotoxicity and aging
University Medical Center Groningen · University of Groningen · +1 more institution
Abstract
The population of cancer survivors is rapidly increasing due to improving healthcare. However, cancer therapies often have long-term side effects. One example is cancer therapy-related cardiac dysfunction (CTRCD) caused by doxorubicin: up to 9% of the cancer patients treated with this drug develop heart failure at a later stage. In recent years, doxorubicin-induced cardiotoxicity has been associated with an accelerated aging phenotype and cellular senescence in the heart. In this review we explain the evidence of an accelerated aging phenotype in the doxorubicin-treated heart by comparing it to healthy aged hearts, and shed light on treatment strategies that are proposed in pre-clinical settings. We will…
Citation impact
- FWCI
- 70.12
- Percentile
- 100%
- References
- 186
Authors
6- ANAnnet N. LindersCorresponding
University Medical Center Groningen, University of Groningen
- IBItamar Braga Dias
University Medical Center Groningen, University of Groningen
- TLTeresa López‐Fernández
- CGCarlo G. Tocchetti
Federico II University Hospital
- NBNils Bömer
University Medical Center Groningen, University of Groningen
Topics & keywords
- Cardiotoxicity
- Medicine
- Doxorubicin
- Cancer
- Heart failure
- Senescence
- Cardiac dysfunction
- Population
- Good health and well-being