The interaction between ageing and Alzheimer's disease: insights from the hallmarks of ageing
Central South University · National Clinical Research Center for Digestive Diseases · +4 more institutions
Abstract
Ageing is a crucial risk factor for Alzheimer's disease (AD) and is characterised by systemic changes in both intracellular and extracellular microenvironments that affect the entire body instead of a single organ. Understanding the specific mechanisms underlying the role of ageing in disease development can facilitate the treatment of ageing-related diseases, such as AD. Signs of brain ageing have been observed in both AD patients and animal models. Alleviating the pathological changes caused by brain ageing can dramatically ameliorate the amyloid beta- and tau-induced neuropathological and memory impairments, indicating that ageing plays a crucial role in the pathophysiological process of AD. In this review,…
Citation impact
- FWCI
- 33.27
- Percentile
- 100%
- References
- 314
Authors
6- YLYuqing LiuCorresponding
Central South University, National Clinical Research Center for Digestive Diseases, Second Xiangya Hospital of Central South University
- YTYejun Tan
University of Minnesota, Twin Cities Orthopedics
- ZZZheyu Zhang
Central South University, National Clinical Research Center for Digestive Diseases, Second Xiangya Hospital of Central South University
- MYMin Yi
Central South University, National Clinical Research Center for Digestive Diseases, Second Xiangya Hospital of Central South University
- LZLemei Zhu
Changsha Medical University
Topics & keywords
- Ageing
- Disease
- Neuroscience
- Pathological
- Neurology
- Cognitive decline
- Dementia
- Medicine
- Good health and well-being