Indole-3-Propionic Acid Protects Against Heart Failure With Preserved Ejection Fraction
Institute of Human Genetics · Pediatrics and Genetics · +17 more institutions
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Abstract
Background
Heart failure with preserved ejection fraction (HFpEF) is a common but poorly understood form of heart failure, characterized by impaired diastolic function. It is highly heterogeneous with multiple comorbidities, including obesity and diabetes, making human studies difficult.
Methods
Metabolomic analyses in a mouse model of HFpEF showed that levels of indole-3-propionic acid (IPA), a metabolite produced by gut bacteria from tryptophan, were reduced in the plasma and heart tissue of HFpEF mice as compared with controls. We then examined the role of IPA in mouse models of HFpEF as well as 2 human HFpEF cohorts.
Citation impact
111
total citations
- FWCI
- 41.66
- Percentile
- 100%
- References
- 78
Citations per year
Authors
16Topics & keywords
Topics
Keywords
- Heart failure with preserved ejection fraction
- Heart failure
- SIRT3
- Nicotinamide
- Internal medicine
- Diastole
- Endocrinology
- Medicine
UN Sustainable Development Goals
- Good health and well-being
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