articleCancer CellJan 25, 2024HYBRID OA

Tumor- and circulating-free DNA methylation identifies clinically relevant small cell lung cancer subtypes

SHSimon HeekeCMCarl M. GayMRMarcos R. EstecioHTHai T. TranBBBenjamin B. Morris

The University of Texas MD Anderson Cancer Center · Hospital Del Mar · +9 more institutions

PubMed
Indexed incrossrefdatacitepubmed

Abstract

Small cell lung cancer (SCLC) is an aggressive malignancy composed of distinct transcriptional subtypes, but implementing subtyping in the clinic has remained challenging, particularly due to limited tissue availability. Given the known epigenetic regulation of critical SCLC transcriptional programs, we hypothesized that subtype-specific patterns of DNA methylation could be detected in tumor or blood from SCLC patients. Using genomic-wide reduced-representation bisulfite sequencing (RRBS) in two cohorts totaling 179 SCLC patients and using machine learning approaches, we report a highly accurate DNA methylation-based classifier (SCLC-DMC) that can distinguish SCLC subtypes. We further adjust the classifier for…

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Topics & keywords

Topics
Keywords
  • Subtyping
  • DNA methylation
  • Epigenetics
  • Biology
  • Lung cancer
  • Malignancy
  • Cancer research
  • Methylation
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